Journal article
Inter-scanner Aβ-PET harmonization using barrel phantom spatial resolution matching
Gihan P Ruwanpathirana, Robert C Williams, Colin L Masters, Christopher C Rowe, Leigh A Johnston, Catherine E Davey
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring | Wiley | Published : 2024
DOI: 10.1002/dad2.12561
Abstract
INTRODUCTION: The standardized uptake value ratio (SUVR) is used to measure amyloid beta–positron emission tomography (Aβ-PET) uptake in the brainDifferences in PET scanner technologies and image reconstruction techniques can lead to variability in PET images across scanners. This poses a challenge for Aβ-PET studies conducted in multiple centers. The aim of harmonization is to achieve consistent Aβ-PET measurements across different scanners. In this study, we propose an Aβ-PET harmonization method of matching spatial resolution, as measured via a barrel phantom, across PET scanners. Our approach was validated using paired subject data, for which patients were imaged on multiple scanners. ME..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Melbourne Brain Center Imaging Unit, the University of Melbourne. The first author would also like to acknowledge the Rowden White scholarship for its assistance in his research. The authors acknowledge the contributions of the the research teams at the Australian Imaging, Biomarker and Lifestyle (AIBL). The research was supported by National Health and Medical Research Council grants 1152623, 1140853 and 1132604.